Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 25 Researches
7.3
USERS' SCORE
Moderately Good
Based on 6 Reviews
7.2
Supplement Facts
Serving Size: 1 Vegetable Capsule
Amount Per Serving
%DV
Vitamin D3 (as cholecalciferol)
125 mcg (5000 IU)
625%
Top Medical Research Studies
9
We explored how Vitamin D3 impacts autoimmune thyroiditis, a specific autoimmune disorder. In this study, researchers established a mouse model of experimental autoimmune thyroiditis (EAT) to see how Vitamin D3 could influence this condition. After eight weeks of treatment, they assessed thyroid health and immune response through various methods, including staining tissues and measuring hormone levels.
Our observations revealed that administering Vitamin D3 helped reduce damage to the thyroid and decreased the presence of inflammatory cells within the thyroid. This treatment also led to lower levels of thyroid hormones and autoimmune antibodies in the blood, highlighting its positive effect on thyroid function. Additionally, Vitamin D3 appeared to promote the regulatory T cell (Treg) subset while decreasing the levels of Th17 cells, which are often involved in autoimmune processes.
Mechanistically, the study found that Vitamin D3 triggered specific pathways that influence Treg cell activity and survival. Notably, it activated a signaling pathway involving YAP and JAK/STAT, which are crucial for immune cell regulation. These findings suggest that Vitamin D3 could play a significant role in balancing immune responses in autoimmune thyroiditis, making it a promising candidate for further research and potential treatment strategies.
Our observations revealed that administering Vitamin D3 helped reduce damage to the thyroid and decreased the presence of inflammatory cells within the thyroid. This treatment also led to lower levels of thyroid hormones and autoimmune antibodies in the blood, highlighting its positive effect on thyroid function. Additionally, Vitamin D3 appeared to promote the regulatory T cell (Treg) subset while decreasing the levels of Th17 cells, which are often involved in autoimmune processes.
Mechanistically, the study found that Vitamin D3 triggered specific pathways that influence Treg cell activity and survival. Notably, it activated a signaling pathway involving YAP and JAK/STAT, which are crucial for immune cell regulation. These findings suggest that Vitamin D3 could play a significant role in balancing immune responses in autoimmune thyroiditis, making it a promising candidate for further research and potential treatment strategies.
Read More
9.5
Vitamin D3 aids autoimmune thyroiditis
We observed that vitamin D3 supplementation may play a significant role in managing autoimmune thyroiditis, a condition often marked by thyroid inflammation. In this study, researchers induced autoimmune thyroiditis in female mice and administered vitamin D3 to evaluate its effects on the disease.
After eight weeks of treatment, the results showed a notable reduction in thyroid damage and lower levels of thyroid autoantibodies in the mice receiving vitamin D3. Specifically, the vitamin appeared to inhibit the activity of certain inflammatory immune cells, which are typically elevated in autoimmune conditions. At the same time, it seemed to support the activity of regulatory immune cells that help keep inflammation in check.
This study highlights the potential of vitamin D3 as a therapeutic option to mitigate the effects of autoimmune thyroiditis, suggesting that it could help balance the immune response in affected individuals. As researchers continue to delve into the role of vitamin D in autoimmune disorders, findings like these support the notion that maintaining adequate vitamin D levels might be crucial for immune health.
After eight weeks of treatment, the results showed a notable reduction in thyroid damage and lower levels of thyroid autoantibodies in the mice receiving vitamin D3. Specifically, the vitamin appeared to inhibit the activity of certain inflammatory immune cells, which are typically elevated in autoimmune conditions. At the same time, it seemed to support the activity of regulatory immune cells that help keep inflammation in check.
This study highlights the potential of vitamin D3 as a therapeutic option to mitigate the effects of autoimmune thyroiditis, suggesting that it could help balance the immune response in affected individuals. As researchers continue to delve into the role of vitamin D in autoimmune disorders, findings like these support the notion that maintaining adequate vitamin D levels might be crucial for immune health.
Read More
9
We aimed to understand how vitamin D3, specifically its active form 1,25(OH)D, affects autoimmune hepatitis (AIH), a complex autoimmune disease that causes liver damage. Researchers focused on the role of a special type of immune cell known as dendritic cells (DCs), which are influenced by vitamin D3 to promote a more balanced immune response.
Through our investigation using a mouse model, we observed that injecting these vitamin D3-modulated dendritic cells, which overexpress a molecule called PD-L1, significantly lessened liver injury and severity of autoimmune hepatitis. This treatment appeared to correct the imbalance between two types of T cells: regulatory T cells (TFR) and follicular helper T cells (TFH).
By increasing the TFR population and restoring their balance with TFH cells, vitamin D3 treatment helped regulate this immune response. Additionally, the infusion boosted the production of anti-inflammatory substances while decreasing those linked to inflammation, suggesting a potential new avenue for treating autoimmune hepatitis. Overall, these findings indicate that vitamin D3-modulated dendritic cells could be a promising strategy for managing autoimmune conditions like AIH.
Through our investigation using a mouse model, we observed that injecting these vitamin D3-modulated dendritic cells, which overexpress a molecule called PD-L1, significantly lessened liver injury and severity of autoimmune hepatitis. This treatment appeared to correct the imbalance between two types of T cells: regulatory T cells (TFR) and follicular helper T cells (TFH).
By increasing the TFR population and restoring their balance with TFH cells, vitamin D3 treatment helped regulate this immune response. Additionally, the infusion boosted the production of anti-inflammatory substances while decreasing those linked to inflammation, suggesting a potential new avenue for treating autoimmune hepatitis. Overall, these findings indicate that vitamin D3-modulated dendritic cells could be a promising strategy for managing autoimmune conditions like AIH.
Read More
Most Useful Reviews
9
Quick recovery
1 people found this helpful
Quick result! After my first order during COVID, my vitamin D levels rose from 18 to normal within a month and a half. Despite limited sun exposure, a month of taking this product raised my levels from 27 to 41.
Read More
9
Energy boost
1 people found this helpful
The best vitamins! At 36, my vitamin D was low at 30 ng/ml, but after taking these, it surged to 65. I feel energised, a stark contrast to my previous fatigue levels, and I'm keen to continue using these vitamins.
Read More
0
Disappointing results
5 people found this helpful
Vegan full of nonsense! I used to raise my vitamin D from less than 3 to 40 with Solgar, but these vegan capsules caused my levels to drop to 37 after several months, despite daily intake of 10,000-15,000 IU.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 25 Researches
7.3
- All Researches
9.5
Vitamin D3 aids autoimmune thyroiditis
We observed that vitamin D3 supplementation may play a significant role in managing autoimmune thyroiditis, a condition often marked by thyroid inflammation. In this study, researchers induced autoimmune thyroiditis in female mice and administered vitamin D3 to evaluate its effects on the disease.
After eight weeks of treatment, the results showed a notable reduction in thyroid damage and lower levels of thyroid autoantibodies in the mice receiving vitamin D3. Specifically, the vitamin appeared to inhibit the activity of certain inflammatory immune cells, which are typically elevated in autoimmune conditions. At the same time, it seemed to support the activity of regulatory immune cells that help keep inflammation in check.
This study highlights the potential of vitamin D3 as a therapeutic option to mitigate the effects of autoimmune thyroiditis, suggesting that it could help balance the immune response in affected individuals. As researchers continue to delve into the role of vitamin D in autoimmune disorders, findings like these support the notion that maintaining adequate vitamin D levels might be crucial for immune health.
After eight weeks of treatment, the results showed a notable reduction in thyroid damage and lower levels of thyroid autoantibodies in the mice receiving vitamin D3. Specifically, the vitamin appeared to inhibit the activity of certain inflammatory immune cells, which are typically elevated in autoimmune conditions. At the same time, it seemed to support the activity of regulatory immune cells that help keep inflammation in check.
This study highlights the potential of vitamin D3 as a therapeutic option to mitigate the effects of autoimmune thyroiditis, suggesting that it could help balance the immune response in affected individuals. As researchers continue to delve into the role of vitamin D in autoimmune disorders, findings like these support the notion that maintaining adequate vitamin D levels might be crucial for immune health.
Read More
9
We explored an intriguing instance of IgG4-related disease (IgG4-RD) manifesting as Mikulicz syndrome in an 85-year-old male patient. This condition usually involves significant systemic symptoms, yet our patient exhibited primarily local manifestations, specifically bilateral dacryoadenitis and orbital pseudotumor, without major organ complications.
Interestingly, despite normal serum IgG4 levels, which were below 135 mg/dL, the clinical and imaging findings strongly suggested the diagnosis of IgG4-RD. This scenario underscores the importance of undertaking a biopsy for accurate diagnosis. Histopathological examination revealed notable signs, such as a dense lymphoplasmacytic infiltrate and storiform fibrosis, with a considerable percentage of IgG4-positive cells, ultimately confirming our diagnosis.
We observed that treatment with prednisone, alongside azathioprine for long-term control, was effective. To mitigate the risk of glucocorticoid-induced osteoporosis, we added calcium and vitamin D3 supplementation. Remarkably, the patient showed significant clinical improvement within just 24 hours, with resolution of orbital and glandular symptoms over the following year. There was a complete recovery of vision and no relapses, with only minor dry eye as a long-term concern.
This case demonstrates the necessity of considering IgG4-RD even when serum IgG4 levels are normal and highlights the role of histopathology in diagnosis. Furthermore, it showcases the effectiveness of corticosteroids as a first-line treatment in managing this condition.
Interestingly, despite normal serum IgG4 levels, which were below 135 mg/dL, the clinical and imaging findings strongly suggested the diagnosis of IgG4-RD. This scenario underscores the importance of undertaking a biopsy for accurate diagnosis. Histopathological examination revealed notable signs, such as a dense lymphoplasmacytic infiltrate and storiform fibrosis, with a considerable percentage of IgG4-positive cells, ultimately confirming our diagnosis.
We observed that treatment with prednisone, alongside azathioprine for long-term control, was effective. To mitigate the risk of glucocorticoid-induced osteoporosis, we added calcium and vitamin D3 supplementation. Remarkably, the patient showed significant clinical improvement within just 24 hours, with resolution of orbital and glandular symptoms over the following year. There was a complete recovery of vision and no relapses, with only minor dry eye as a long-term concern.
This case demonstrates the necessity of considering IgG4-RD even when serum IgG4 levels are normal and highlights the role of histopathology in diagnosis. Furthermore, it showcases the effectiveness of corticosteroids as a first-line treatment in managing this condition.
Read More
9
We aimed to understand how vitamin D3, specifically its active form 1,25(OH)D, affects autoimmune hepatitis (AIH), a complex autoimmune disease that causes liver damage. Researchers focused on the role of a special type of immune cell known as dendritic cells (DCs), which are influenced by vitamin D3 to promote a more balanced immune response.
Through our investigation using a mouse model, we observed that injecting these vitamin D3-modulated dendritic cells, which overexpress a molecule called PD-L1, significantly lessened liver injury and severity of autoimmune hepatitis. This treatment appeared to correct the imbalance between two types of T cells: regulatory T cells (TFR) and follicular helper T cells (TFH).
By increasing the TFR population and restoring their balance with TFH cells, vitamin D3 treatment helped regulate this immune response. Additionally, the infusion boosted the production of anti-inflammatory substances while decreasing those linked to inflammation, suggesting a potential new avenue for treating autoimmune hepatitis. Overall, these findings indicate that vitamin D3-modulated dendritic cells could be a promising strategy for managing autoimmune conditions like AIH.
Through our investigation using a mouse model, we observed that injecting these vitamin D3-modulated dendritic cells, which overexpress a molecule called PD-L1, significantly lessened liver injury and severity of autoimmune hepatitis. This treatment appeared to correct the imbalance between two types of T cells: regulatory T cells (TFR) and follicular helper T cells (TFH).
By increasing the TFR population and restoring their balance with TFH cells, vitamin D3 treatment helped regulate this immune response. Additionally, the infusion boosted the production of anti-inflammatory substances while decreasing those linked to inflammation, suggesting a potential new avenue for treating autoimmune hepatitis. Overall, these findings indicate that vitamin D3-modulated dendritic cells could be a promising strategy for managing autoimmune conditions like AIH.
Read More
9
We investigated the effects of Vitamin D modulation on autoimmune prostatitis using a mouse model. In this study, we focused on how changes in gut microbiota influence the immune response, specifically looking at how vitamin D can help shift macrophage polarization—key players in the immune system—from a pro-inflammatory state (M1) to a more healing state (M2).
We observed that treatment with Eriocalyxin B (EriB), known for its anti-inflammatory properties, significantly reduced prostate inflammation in these mice. Our findings indicate that EriB not only altered the gut microbiome but also enhanced the absorption of vitamin D, contributing to a shift in macrophage phenotype. This suggests that the immune state of macrophages, altered through gut bacteria and vitamin D levels, plays a crucial role in managing autoimmune prostatitis.
Notably, fecal transplantation from EriB-treated mice resulted in a marked reduction in inflammatory markers and further supported the macrophage polarization effect. This is the first time we connected gut microbiota and vitamin D as pivotal factors in the treatment of autoimmune disorders like chronic prostatitis, highlighting a new therapeutic pathway. Overall, our research emphasizes the importance of vitamin D in modulating autoimmune responses through gut health.
We observed that treatment with Eriocalyxin B (EriB), known for its anti-inflammatory properties, significantly reduced prostate inflammation in these mice. Our findings indicate that EriB not only altered the gut microbiome but also enhanced the absorption of vitamin D, contributing to a shift in macrophage phenotype. This suggests that the immune state of macrophages, altered through gut bacteria and vitamin D levels, plays a crucial role in managing autoimmune prostatitis.
Notably, fecal transplantation from EriB-treated mice resulted in a marked reduction in inflammatory markers and further supported the macrophage polarization effect. This is the first time we connected gut microbiota and vitamin D as pivotal factors in the treatment of autoimmune disorders like chronic prostatitis, highlighting a new therapeutic pathway. Overall, our research emphasizes the importance of vitamin D in modulating autoimmune responses through gut health.
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9
We observed a fascinating interplay between vitamin D3 and immune responses in patients with multiple sclerosis (MS), an autoimmune disorder that leads to significant neurological damage. Our focus was on a type of immune cell called tolerogenic dendritic cells (tolDCs), which help maintain a balance in the immune system. In our study, we used monocytes from both healthy donors and treatment-naive MS patients to assess how these cells behaved under different conditions.
Our findings revealed that tolDCs derived from MS patients had reduced tolerogenic properties when compared to their healthy counterparts. To our surprise, we found that direct activation of the aryl hydrocarbon receptor (AhR), a key player in immune regulation, could restore the tolerogenic features of MS patient-derived tolDCs. Furthermore, when we combined this approach with a treatment known as dimethyl fumarate (DMF), the results were even more promising.
The combination therapy of DMF and vitamin D3-tolDCs not only improved the tolerogenic effects but also showed better results in an experimental model of MS than using either treatment alone. This suggests that we may have a novel and effective strategy for enhancing immune tolerance in autoimmune diseases like MS.
Overall, our research indicates that vitamin D3, when used alongside DMF, could offer a new pathway for treatment, potentially minimizing the need for broader immunosuppression. This discovery opens up exciting possibilities for better management of autoimmune conditions in the future.
Our findings revealed that tolDCs derived from MS patients had reduced tolerogenic properties when compared to their healthy counterparts. To our surprise, we found that direct activation of the aryl hydrocarbon receptor (AhR), a key player in immune regulation, could restore the tolerogenic features of MS patient-derived tolDCs. Furthermore, when we combined this approach with a treatment known as dimethyl fumarate (DMF), the results were even more promising.
The combination therapy of DMF and vitamin D3-tolDCs not only improved the tolerogenic effects but also showed better results in an experimental model of MS than using either treatment alone. This suggests that we may have a novel and effective strategy for enhancing immune tolerance in autoimmune diseases like MS.
Overall, our research indicates that vitamin D3, when used alongside DMF, could offer a new pathway for treatment, potentially minimizing the need for broader immunosuppression. This discovery opens up exciting possibilities for better management of autoimmune conditions in the future.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 6 Reviews
7.2
- All Reviews
- Positive Reviews
- Negative Reviews
9
Quick recovery
1 people found this helpful
Quick result! After my first order during COVID, my vitamin D levels rose from 18 to normal within a month and a half. Despite limited sun exposure, a month of taking this product raised my levels from 27 to 41.
Read More
9
Energy boost
1 people found this helpful
The best vitamins! At 36, my vitamin D was low at 30 ng/ml, but after taking these, it surged to 65. I feel energised, a stark contrast to my previous fatigue levels, and I'm keen to continue using these vitamins.
Read More
0
Disappointing results
5 people found this helpful
Vegan full of nonsense! I used to raise my vitamin D from less than 3 to 40 with Solgar, but these vegan capsules caused my levels to drop to 37 after several months, despite daily intake of 10,000-15,000 IU.
Read More
2
Ineffective formula
4 people found this helpful
Does not work! I mistakenly ordered vitamin in powder form instead of oil. My levels fell from 46 to 40 over two months, even with sunny weather. I won’t be using this form again due to its ineffectiveness in my autoimmune disorder treatment.
Read More
7.5
Positive outcomes
1 people found this helpful
Excellent! This product has significantly improved my vitamin D levels. Previously, my levels increased from 10-12 to 26-30 with Solgar 10000. I have now switched to 5000 and am monitoring my progress with blood tests as my endocrinologist adjusts the dosage.
Read More
Frequently Asked Questions
9
Quick recovery
1 people found this helpful
Quick result! After my first order during COVID, my vitamin D levels rose from 18 to normal within a month and a half. Despite limited sun exposure, a month of taking this product raised my levels from 27 to 41.
9
Energy boost
1 people found this helpful
The best vitamins! At 36, my vitamin D was low at 30 ng/ml, but after taking these, it surged to 65. I feel energised, a stark contrast to my previous fatigue levels, and I'm keen to continue using these vitamins.
0
Disappointing results
5 people found this helpful
Vegan full of nonsense! I used to raise my vitamin D from less than 3 to 40 with Solgar, but these vegan capsules caused my levels to drop to 37 after several months, despite daily intake of 10,000-15,000 IU.
2
Ineffective formula
4 people found this helpful
Does not work! I mistakenly ordered vitamin in powder form instead of oil. My levels fell from 46 to 40 over two months, even with sunny weather. I won’t be using this form again due to its ineffectiveness in my autoimmune disorder treatment.
7.5
Positive outcomes
1 people found this helpful
Excellent! This product has significantly improved my vitamin D levels. Previously, my levels increased from 10-12 to 26-30 with Solgar 10000. I have now switched to 5000 and am monitoring my progress with blood tests as my endocrinologist adjusts the dosage.
7.5
Effective treatment
1 people found this helpful
Working drug! I ordered this for a friend who meticulously checks her vitamin D levels. After one month of use, her levels increased from 30 to 60, demonstrating its effectiveness in managing her autoimmune disorder.
9.5
Vitamin D3 aids autoimmune thyroiditis
We observed that vitamin D3 supplementation may play a significant role in managing autoimmune thyroiditis, a condition often marked by thyroid inflammation. In this study, researchers induced autoimmune thyroiditis in female mice and administered vitamin D3 to evaluate its effects on the disease.
After eight weeks of treatment, the results showed a notable reduction in thyroid damage and lower levels of thyroid autoantibodies in the mice receiving vitamin D3. Specifically, the vitamin appeared to inhibit the activity of certain inflammatory immune cells, which are typically elevated in autoimmune conditions. At the same time, it seemed to support the activity of regulatory immune cells that help keep inflammation in check.
This study highlights the potential of vitamin D3 as a therapeutic option to mitigate the effects of autoimmune thyroiditis, suggesting that it could help balance the immune response in affected individuals. As researchers continue to delve into the role of vitamin D in autoimmune disorders, findings like these support the notion that maintaining adequate vitamin D levels might be crucial for immune health.
After eight weeks of treatment, the results showed a notable reduction in thyroid damage and lower levels of thyroid autoantibodies in the mice receiving vitamin D3. Specifically, the vitamin appeared to inhibit the activity of certain inflammatory immune cells, which are typically elevated in autoimmune conditions. At the same time, it seemed to support the activity of regulatory immune cells that help keep inflammation in check.
This study highlights the potential of vitamin D3 as a therapeutic option to mitigate the effects of autoimmune thyroiditis, suggesting that it could help balance the immune response in affected individuals. As researchers continue to delve into the role of vitamin D in autoimmune disorders, findings like these support the notion that maintaining adequate vitamin D levels might be crucial for immune health.
4
We set out to discover how effective vitamin D is in treating autoimmune disorders, specifically in patients with Hashimoto's thyroiditis (HT). Our analysis involved looking at several studies examining various dietary supplements, including selenium and vitamin D, to see how they impact thyroid autoantibody levels and overall thyroid function.
Within the studies we reviewed, vitamin D did not seem to significantly reduce thyroid autoantibody levels like other supplements. In particular, we noted that treatments involving vitamin D, whether alone or in combination with other nutrients, did not show a meaningful effect on reducing thyroid peroxidase autoantibodies (TPOAb) or thyroglobulin autoantibodies (TgAb).
This lack of significant benefit suggests that while vitamin D is often included in treatment plans for autoimmune disorders, it may not play a critical role in alleviating the symptoms or autoimmunity associated with HT. Therefore, it might be wise for those seeking supplemental help to consider other options, particularly selenium, which showed more promising results.
Within the studies we reviewed, vitamin D did not seem to significantly reduce thyroid autoantibody levels like other supplements. In particular, we noted that treatments involving vitamin D, whether alone or in combination with other nutrients, did not show a meaningful effect on reducing thyroid peroxidase autoantibodies (TPOAb) or thyroglobulin autoantibodies (TgAb).
This lack of significant benefit suggests that while vitamin D is often included in treatment plans for autoimmune disorders, it may not play a critical role in alleviating the symptoms or autoimmunity associated with HT. Therefore, it might be wise for those seeking supplemental help to consider other options, particularly selenium, which showed more promising results.
8
We explored the significant role of vitamin D in managing rheumatoid arthritis (RA), a chronic autoimmune disorder characterized by joint inflammation and damage. The evidence points to a common deficiency in vitamin D among RA patients, which can be linked to increased severity of the disease.
Our observations suggest that vitamin D may help modulate the immune response and reduce inflammation. There has been promising data showing that vitamin D supplementation can lead to improvements in disease activity, as well as a decrease in inflammatory markers among patients.
In addition to its immune-boosting properties, we recognized that managing vitamin D levels might also alleviate some of the symptoms associated with RA, such as fatigue, which can be exacerbated by deficiencies. Overall, the compelling findings underline the potential benefits of vitamin D as a therapeutic option for patients dealing with autoimmune disorders like RA.
Our observations suggest that vitamin D may help modulate the immune response and reduce inflammation. There has been promising data showing that vitamin D supplementation can lead to improvements in disease activity, as well as a decrease in inflammatory markers among patients.
In addition to its immune-boosting properties, we recognized that managing vitamin D levels might also alleviate some of the symptoms associated with RA, such as fatigue, which can be exacerbated by deficiencies. Overall, the compelling findings underline the potential benefits of vitamin D as a therapeutic option for patients dealing with autoimmune disorders like RA.
8
We explored the connection between vitamin D levels and the management of Graves' disease, an autoimmune disorder characterized by overactive thyroid function. Through our research with 171 patients, we aimed to see if pre-treatment levels of 25-hydroxyvitamin D could influence the reduction of thyrotropin receptor antibodies (TRAB) during treatment.
Our study divided patients into three groups based on their vitamin D levels: less than 20 ng/mL, between 20-29 ng/mL, and 30 ng/mL or more. The findings were quite revealing. We observed that patients with vitamin D levels ranging from 20 to 29 ng/mL experienced significantly higher rates of TRAB remission and negative conversion compared to the other groups during follow-ups at 6, 12, and 24 months.
This suggests that maintaining vitamin D within this specific range can be beneficial for patients newly diagnosed with Graves' disease as they undergo antithyroid treatment. However, we noted that vitamin D levels did not seem to affect the normalization of free triiodothyronine and free thyroxine levels over time.
In summary, our findings emphasize the potential role of adequate vitamin D levels in supporting immune regulation and therapeutic outcomes in autoimmune disorders, particularly Graves' disease.
Our study divided patients into three groups based on their vitamin D levels: less than 20 ng/mL, between 20-29 ng/mL, and 30 ng/mL or more. The findings were quite revealing. We observed that patients with vitamin D levels ranging from 20 to 29 ng/mL experienced significantly higher rates of TRAB remission and negative conversion compared to the other groups during follow-ups at 6, 12, and 24 months.
This suggests that maintaining vitamin D within this specific range can be beneficial for patients newly diagnosed with Graves' disease as they undergo antithyroid treatment. However, we noted that vitamin D levels did not seem to affect the normalization of free triiodothyronine and free thyroxine levels over time.
In summary, our findings emphasize the potential role of adequate vitamin D levels in supporting immune regulation and therapeutic outcomes in autoimmune disorders, particularly Graves' disease.
8
Our investigation focused on the role of vitamin D in the autoimmune disorder known as alopecia areata (AA). We delved into data from various studies, including a meta-analysis of 34 papers covering nearly 5,000 participants from multiple countries.
The findings demonstrated a clear association between low vitamin D levels and increased risk of AA. Specifically, patients with alopecia areata exhibited significantly lower serum vitamin D levels compared to healthy individuals. In fact, those with vitamin D deficiency were found to be at a higher risk of developing the condition.
These results suggest that vitamin D supplementation could potentially serve as an effective treatment strategy for individuals suffering from AA. However, it’s important to note that while vitamin D showed promise, the study did not find significant differences in other trace elements, such as copper, in relation to AA.
Overall, our research underscores the importance of maintaining adequate vitamin D levels, as it may play a crucial role in the management of autoimmune disorders like alopecia areata.
The findings demonstrated a clear association between low vitamin D levels and increased risk of AA. Specifically, patients with alopecia areata exhibited significantly lower serum vitamin D levels compared to healthy individuals. In fact, those with vitamin D deficiency were found to be at a higher risk of developing the condition.
These results suggest that vitamin D supplementation could potentially serve as an effective treatment strategy for individuals suffering from AA. However, it’s important to note that while vitamin D showed promise, the study did not find significant differences in other trace elements, such as copper, in relation to AA.
Overall, our research underscores the importance of maintaining adequate vitamin D levels, as it may play a crucial role in the management of autoimmune disorders like alopecia areata.
7
We examined the potential impact of vitamin D on autoimmune disorders, specifically focusing on its effects in patients with Antiphospholipid Syndrome (APS). APS is a complex autoimmune condition that leads to issues like blood clots and complications during pregnancy, largely tied to immune system disturbances. Given the uncertain prognosis of APS, current treatment primarily revolves around anticoagulation therapy to prevent blood clots.
Recent research has shed light on how vitamin D might play a beneficial role in regulating immune cells, thus offering hope for those affected by APS. By potentially restoring the balance of immune responses, vitamin D could serve as a valuable complementary treatment alongside conventional therapies. This finding underscores the importance of further exploring vitamin D's mechanisms and its broader applications in autoimmune disorders.
Overall, while vitamin D appears promising as an adjunct therapy for APS, research is still developing. We look forward to seeing how this vitamin could improve immune regulation for patients dealing with challenges related to autoimmune diseases.
Recent research has shed light on how vitamin D might play a beneficial role in regulating immune cells, thus offering hope for those affected by APS. By potentially restoring the balance of immune responses, vitamin D could serve as a valuable complementary treatment alongside conventional therapies. This finding underscores the importance of further exploring vitamin D's mechanisms and its broader applications in autoimmune disorders.
Overall, while vitamin D appears promising as an adjunct therapy for APS, research is still developing. We look forward to seeing how this vitamin could improve immune regulation for patients dealing with challenges related to autoimmune diseases.
References
- Vernerová L, Vokurková M, Laiferová NA, Nemec M, Špiritović M, et al. Vitamin D and its receptor in skeletal muscle are associated with muscle disease manifestation, lipid metabolism and physical fitness of patients with myositis. Arthritis Res Ther. 2025;27:48. doi:10.1186/s13075-025-03516-9
- Wang CM, Chen YJ, Yang BC, Yang JW, Wang W, et al. Supplementation with active vitamin D3 ameliorates experimental autoimmune thyroiditis in mice by modulating the differentiation and functionality of intrathyroidal T-cell subsets. Front Immunol. 2025;16:1528707. doi:10.3389/fimmu.2025.1528707
- Chen X, Zhang Y, Lin L, Chen Y, Shen X, et al. A beneficial levels of 25-hydroxyvitamin D for a decrease in thyrotropin receptor antibody (TRAB) in patients with Graves' disease: a real-world study. BMC Endocr Disord. 2025;25:14. doi:10.1186/s12902-024-01823-x
- Rafati A, Ramezani R, Esmaeili Gouvarchin Ghaleh H, Bahrami S, Alvanegh AG, et al. Calcitriol Treated Mesenchymal Stem Cells Modulated Immune Response in Collagen-Induced Rheumatoid Arthritis in BALB/c Mice. Transplant Proc. 2025;57:355. doi:10.1016/j.transproceed.2024.12.020
- Casas R, Tompa A, Åkesson K, Teixeira PF, Lindqvist A, et al. Redosing with Intralymphatic GAD-Alum in the Treatment of Type 1 Diabetes: The DIAGNODE-B Pilot Trial. Int J Mol Sci. 2025;26. doi:10.3390/ijms26010374
- Rasheed A, Khan G. Epstein-Barr virus, vitamin D and the immune response: connections with consequences for multiple sclerosis. Front Immunol. 2024;15:1503808. doi:10.3389/fimmu.2024.1503808
- Wu R, Li Y, Peng H, Yang Z, Wang Y, et al. Association Between Serum Trace Elements Level and Alopecia Areata: A Systematic Review and Meta-Analysis. J Cosmet Dermatol. 2025;24:e16740. doi:10.1111/jocd.16740
- Hijjawi N, Tout FS, Azaizeh B, Aljaafreh B. The role of vitamins D, B12, C, and K in modulating inflammation and disease management in rheumatoid arthritis: a comprehensive review. Clin Rheumatol. 2025;44:591. doi:10.1007/s10067-024-07285-9
- Peng B, Wang W, Gu Q, Wang P, Teng W, et al. Effects of different supplements on Hashimoto's thyroiditis: a systematic review and network meta-analysis. Front Endocrinol (Lausanne). 2024;15:1445878. doi:10.3389/fendo.2024.1445878
- Balshi A, Leuenberger G, Dempsey J, Baber U, Sloane JA. Glucagon-like peptide-1 agonist safety and efficacy in a multiple sclerosis cohort. Mult Scler Relat Disord. 2025;93:106229. doi:10.1016/j.msard.2024.106229
- Mourelatou NG, Kounatidis D, Jude EB, Rebelos E. Vitamin D Supplementation as a Therapeutic Strategy in Autoimmune Diabetes: Insights and Implications for LADA Management. Nutrients. 2024;16. doi:10.3390/nu16234072
- Huo R, Yang Y, Wei C, Huo X, Meng D, et al. Vitamin D affects antiphospholipid syndrome by regulating T cells (Review). Int J Mol Med. 2025;55. doi:10.3892/ijmm.2024.5471
- Kilani Y, Alsakarneh S, Madi MY, Mosquera DAG, Ferreira MN, et al. Autoimmune Hepatitis and Vitamin D Deficiency: A Nationwide Perspective. Aliment Pharmacol Ther. 2025;61:682. doi:10.1111/apt.18438
- Mendoza-Vargas LÁ, Sevilla-Fuentes S, Bautista-Becerril B, Berthaúd-González B, Falfán-Valencia R, et al. IgG4-RD-Associated Mikulicz Syndrome Without Classic Systemic Involvement-A Case Report. J Clin Med. 2025;14. doi:10.3390/jcm14030958
- Dai J, Song J, Chen X, Ding F, Ding Y, et al. 1,25(OH)D-treated mouse bone marrow-derived dendritic cells alleviate autoimmune hepatitis in mice by improving TFR/TFH imbalance. Immunopharmacol Immunotoxicol. 2025;47:59. doi:10.1080/08923973.2024.2435314
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